abstract：:The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer. The i...

journal_title：Oncology letters

authors： Yang L,Wang XW,Zhu LP,Wang HL,Wang B,Zhao Q,Wang XY

更新日期：2018-08-01 00:00:00

abstract：:The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed...

journal_title：Oncology letters

authors： Dai H,Deng HB,Wang YH,Guo JJ

更新日期：2018-08-01 00:00:00

abstract：:The present study aimed to measure the expression of WNT1 in ameloblastoma (AB). Immunohistochemistry was used to observe changes in WNT1 expression in 80 AB samples, 10 keratocystic odontogenic tumor (KCOT) samples and 10 normal oral mucosa (NOM) samples. Western blotting and reverse transcription-quantitative polyme...

journal_title：Oncology letters

authors： Wang GN,Zhong M,Chen Y,Ji J,Gao XQ,Wang TF

更新日期：2018-08-01 00:00:00

abstract：:Previous studies have shown that the activation of the β2 adrenergic receptor (ADRB2) can stimulate several signaling pathways that promote tumor growth and metastasis. β-adrenergic antagonism may have a beneficial role in cancer treatment; however, little is known about the effect of ADRB2 inhibition on the growth of...

journal_title：Oncology letters

authors： Dang D,Zhang J,Yang J

更新日期：2018-08-01 00:00:00

abstract：:Despite the efficacy of combination chemotherapy with arsenic trioxide (ATO), interferon α (IFN) and zidovudine (AZT) for adult T cell leukemia/lymphoma (ATL), the precise mechanism underlying this combination treatment effect is unknown. In the present study, ATO/IFN/AZT was examined in an ATL leukemic cell line (S1T...

journal_title：Oncology letters

authors： Hachiman M,Yoshimitsu M,Ezinne C,Kuroki A,Kozako T,Arima N

更新日期：2018-07-01 00:00:00

abstract：:Decoy receptor 3 (DcR3) is a tumor necrosis factor receptor, which may inhibit apoptosis. The aim of the present study was to investigate the clinical significance of DcR3 upregulation in patients with chronic hepatitis B (CHB) and hepatic fibrosis. A total of 128 patients with a clinical diagnosis of CHB who underwen...

journal_title：Oncology letters

authors： Lou X,Hou Y,Cao H,Zhao J,Zhu F

更新日期：2018-07-01 00:00:00

abstract：:In the present study, the anti-tumor effects of combination treatment with an siRNA targeting B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E and phosphoinositide 3-kinase (PI3K) signaling pathway inhibitors was investigated in melanoma cell lines harboring BRAFV600E. Human melanoma A375 and WM115 cells were ...

journal_title：Oncology letters

authors： He H,Nan X,Liu S,Zhang L,Yang Z,Wu Y,Zhang L

更新日期：2018-07-01 00:00:00

abstract：:Choroidal melanoma is a rare ocular tumor. The present study reports the case of a 66-year-old male who presented with chronic headache and progressive visual loss. Physical eye examination and combined A- and B-mode ultrasonography detected choroidal melanoma. Due to tumor characteristics the eye was enucleated resto...

journal_title：Oncology letters

authors： Terzidou C,Trivli A,Dalianis G,Apessou D,Spandidos DA,Goulielmos GN

更新日期：2018-07-01 00:00:00

abstract：:microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...

journal_title：Oncology letters

authors： Chen X,Wang A,Yue X

更新日期：2018-07-01 00:00:00

abstract：:Glutathione transferase Mu 1 (GSTM1) induces cancer drug resistance by hydrolyzing cancer chemotherapeutics or activating the anti-apoptosis pathway. However, the chemoresistance-inducing mechanism of GSTM1 in hepatocellular carcinoma (HCC) remains unknown. In the present study, the expression of GSTM1 was examined in...

journal_title：Oncology letters

authors： Fu XT,Song K,Zhou J,Shi YH,Liu WR,Tian MX,Jin L,Shi GM,Gao Q,Ding ZB,Fan J

更新日期：2018-07-01 00:00:00

abstract：:The present study aimed to investigate the expression levels of microRNA (miR)-23a and miR-23b in the tumor tissues of patients with ovarian cancer. The study also explored the correlation of miR-23a and miR-23b expression levels in the tumor tissues with the clinic-pathological parameters and prognosis of the patient...

journal_title：Oncology letters

authors： Su L,Liu M

更新日期：2018-07-01 00:00:00

abstract：:Ovarian endometrioid borderline tumors (EBTs) are extremely rare, and are thought to be precursors of endometrioid carcinoma, beginning as adenofibroma or endometriosis and progressing in a slow, stepwise manner. In endometrioid carcinomas, a high frequency of activating mutations in phosphatase and tensin homolog (PT...

journal_title：Oncology letters

authors： Nakamura K,Nakayama K,Ishikawa M,Minamoto T,Ishibashi T,Sato E,Sanuki K,Yamashita H,Ono R,Iida K,Sultana R,Hossain MM,Ishikawa N,Kyo S

更新日期：2018-07-01 00:00:00

abstract：:The alteration of microRNA (miR)-130b expression has been associated with promoting or suppressing numerous types of human cancer. A previous study evaluated the expression level of miR-130b in osteosarcoma tissues, and subsequently investigated the effects of miR-130b on the regulation of osteosarcoma cells malignant...

journal_title：Oncology letters

authors： Wu Y,Sun W,Kong Y,Liu B,Zeng M,Wang W

更新日期：2018-07-01 00:00:00

abstract：:Liver kinase B1 (LKB1) encodes a serine/threonine kinase and functions as a tumor suppressor. LKB1 loss-of-function somatic mutations are frequently observed in sporadic types of cancer, particularly in lung cancer. Ectopic LKB1 induces growth arrest by upregulating p21/cyclin dependent kinase inhibitor 1A (WAF1) in L...

journal_title：Oncology letters

authors： Ma Q,Xiao P,Sun L,Wang J,Zhong D

更新日期：2018-07-01 00:00:00

abstract：:Breast cancer affects ~10% of women worldwide and is responsible for ~12% of all cancer-associated mortalities. Breast cancer is more prone to metastasis compared with other types of cancer. Up to 5% of patients with breast cancer present with incurable metastasis and an additional 10-15% of patients develop metastase...

journal_title：Oncology letters

authors： Gao S,Cao C,Dai Q,Chen J,Tu J

更新日期：2018-07-01 00:00:00

abstract：:The use of bronchoscopy is central to the diagnosis of lung cancer. However, the sensitivity of bronchoscopy is low. In addition, bronchial washing cytology, which is a routine adjunctive test, does not significantly improve the performance of bronchoscopy owing to its low sensitivity. To enhance the diagnostic perfor...

journal_title：Oncology letters

authors： Jeong IB,Yoon YS,Park SY,Cha EJ,Na MJ,Kwon SJ,Kim JH,Oh TJ,An S,Park CR,Kim YJ,Park DH,Son JW

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the dynamic intensity-modulated radiation therapy planned γ analysis passing rate and respiratory amplitude (A) and period (T) for different tumor volumes. A total of 30 patients with malignant lung tumors were divided into three groups: A; B; and...

journal_title：Oncology letters

authors： Xie K,Sun H,Lin T,Gao L,Sui J,Ni X

更新日期：2018-07-01 00:00:00

abstract：:The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in PSH versus pulmonary hamartoma. 18F-FDG PE...

journal_title：Oncology letters

authors： Jiang L,Huang Y,Tang Q,Zhao Q,Li Y,Wu X,Wang H

更新日期：2018-07-01 00:00:00

abstract：:Keloids are a type of benign hyperplasia that cause dermatologic dysfunction and esthetic deformity by invading adjacent normal tissues. Little is known about their etiology, therefore, they are a challenge to treat using plastic surgery. In a previous study, it was demonstrated that the expression of the long non-cod...

journal_title：Oncology letters

authors： Li Y,Liang X,Wang P,Long X,Wang X,Meng Z

更新日期：2018-07-01 00:00:00

abstract：:Peritoneal metastasis is an important prognostic factor for pancreatic cancer. The present study evaluated the possibility of diagnosing peritoneal metastasis by a photodynamic diagnosis using 5-aminolevulinic acid (5-ALA-PDD). In vitro, protoporphyrin IX (PpIX) accumulation was examined in the AsPC-1-GFP cell line fo...

journal_title：Oncology letters

authors： Harada K,Murayama Y,Kubo H,Matsuo H,Morimura R,Ikoma H,Fujiwara H,Okamoto K,Tanaka T,Otsuji E

更新日期：2018-07-01 00:00:00

abstract：:Follicular lymphoma (FL) occurs primarily in the gastrointestinal tract, with the stomach being one of the rarest sites. According to the literature, <20 cases of primary gastric FL have been reported, with the number of cases with detailed pathological descriptions being even less. The aim of the present study was to...

journal_title：Oncology letters

authors： Na HY,Kim YA,Lee C,Choe JY,Shin SA,Shim JW,Min SK,Kim HJ,Han JH,Kim JE

更新日期：2018-07-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. ...

journal_title：Oncology letters

authors： Li BS,Huang JY,Guan J,Chen LH

更新日期：2018-07-01 00:00:00

abstract：:Lung cancer remains the leading cause of cancer-associated mortality in China and worldwide. Increasing numbers of studies have demonstrated that microRNAs (miRNAs/miRs) have vital functions in numerous developmental processes and tumorigenesis. The aim of the present study was to investigate miR-154 expression in non...

journal_title：Oncology letters

authors： Liu S,Yang Y,Chen L,Liu D,Dong H

更新日期：2018-06-01 00:00:00

abstract：:Elevated expression of the retinoic acid-metabolizing enzyme cytochrome P450 26A1 (CYP26A1) has been demonstrated to have an oncogenic function in carcinogenesis. In order to address the oncogenic capacity of CYP26A1 in vivo, transgenic mice that ubiquitously overexpressed CYP26A1 driven by the cytomegalovirus promote...

journal_title：Oncology letters

authors： Osanai M,Takasawa A,Takasawa K,Murata M,Sawada N

更新日期：2018-06-01 00:00:00

abstract：:In the present study, the expression level of microRNA-146a-5p (miR-146a-5p) in breast cancer tissue and cell lines was investigated and its effects on proliferation of breast cancer cells. miR-146a-5p expression was detected by reverse transcription-quantitative polymerase chain reaction in breast cancer tissues, par...

journal_title：Oncology letters

authors： Gao W,Hua J,Jia Z,Ding J,Han Z,Dong Y,Lin Q,Yao Y

更新日期：2018-06-01 00:00:00

abstract：:Euchromatic histone-lysine N-methyltransferase (G9A), the primary histone methyltransferase for histone H3 Lys9, has been identified to be upregulated in numerous types of cancer. The aim of the present study was to analyze the clinical significance of G9A, and preliminarily explore its function in hepatocellular carc...

journal_title：Oncology letters

authors： Qin J,Li Q,Zeng Z,Wu P,Jiang Y,Luo T,Ji X,Zhang Q,Hao Y,Chen L

更新日期：2018-06-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) and the interleukin (IL)-23/IL-17A axis serve an important role in tumor immunology. In the present study, the activation of the TLR4/myeloid differentiation primary response 88 (MyD88)-mediated signal transduction pathway in human hepatocellular carcinoma (HCC) cells was examined using imm...

journal_title：Oncology letters

authors： Kang Y,Su G,Sun J,Zhang Y

更新日期：2018-06-01 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by modulating histone methylation and has been associated with numerous high-risk cancers. Previously, our group and others identified LSD1 as an upregulated gene in ovarian cancer, and reported that the upregulation of LSD1 was associated...

journal_title：Oncology letters

authors： Shao G,Wan X,Lai W,Wu C,Jin J,Liu X,Wei Y,Lin Q,Zhang L,Shao Q

更新日期：2018-06-01 00:00:00

abstract：:Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...

journal_title：Oncology letters

authors： Liu J,Mi B,Wang Y,Shi C,Mi X,Lu Y,Yu P

更新日期：2018-06-01 00:00:00

abstract：:MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in...

journal_title：Oncology letters

authors： Lin MH,Chen YZ,Lee MY,Weng KP,Chang HT,Yu SY,Dong BJ,Kuo FR,Hung LT,Liu LF,Chen WS,Tsai KW

更新日期：2018-06-01 00:00:00

abstract：:Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, bu...

journal_title：Oncology letters

authors： Liu D,Li R,Guo X,Pang L,Zang Y,Liu K,Chen D

更新日期：2018-06-01 00:00:00

abstract：:The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of th...

journal_title：Oncology letters

authors： Kobayashi J,Fujimoto D,Murakami M,Hirono Y,Goi T

更新日期：2018-06-01 00:00:00

abstract：:MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted...

journal_title：Oncology letters

authors： Palkina N,Komina A,Aksenenko M,Moshev A,Savchenko A,Ruksha T

更新日期：2018-06-01 00:00:00

abstract：:Maternal embryonic leucine zipper kinase (MELK) is an important regulator in tumorigenesis of human breast cancer, and if silenced leads to programmed cell death in specific breast cancer cell lines, including MDA-MB-231 cells. In the present study, RNA interference, proliferation assay and semi-quantification of cell...

journal_title：Oncology letters

authors： Li G,Yang M,Zuo L,Wang MX

更新日期：2018-06-01 00:00:00

abstract：:Patients diagnosed preoperatively with ductal carcinoma in situ (DCIS) breast cancer have the potential to develop invasive ductal carcinoma (IDC). The present study investigated the usefulness of exosome-encapsulated microRNA-223-3p (miR-223-3p) as a biomarker for detecting IDC in patients initially diagnosed with DC...

journal_title：Oncology letters

authors： Yoshikawa M,Iinuma H,Umemoto Y,Yanagisawa T,Matsumoto A,Jinno H

更新日期：2018-06-01 00:00:00

abstract：:The present study aims to investigate the radiosensitization effect of the migration and invasion inhibitory protein (MIIP) gene on nasopharyngeal carcinoma (NPC) cells. The MIIP gene was transfected into NPC 5-8F and CNE2 cells. The level of MIIP was analyzed by quantitative reverse transcription-polymerase chain rea...

journal_title：Oncology letters

authors： Zhou HP,Qian LX,Zhang N,Gu JJ,Ding K,Wu J,Lu ZW,Du MY,Zhu HM,Wu JZ,He X,Yin L

更新日期：2018-06-01 00:00:00

abstract：:5-lipoxygenase (5-LO) catalyzes the first step of arachidonic acid metabolism to inflammatory mediator leukotrienes. The present study assessed 5-LO expression in esophageal squamous cell carcinoma (ESCC) tissue specimens for associations with clinicopathological and survival data from patients, then explored 5-LO act...

journal_title：Oncology letters

authors： Bai CY,Zhang JY,Shi TW,Bai YQ,Wu BL,Du ZP,Wu ZY,Xu XE,Wang SH,Wu JY,Te RY,Zhang JY,Xu LY,Li EM

更新日期：2018-06-01 00:00:00

abstract：:Nucleobindin 2 (NUCB2) is mainly expressed in the hypothalamic nuclei and has a proven role in energy homeostasis. It has also been recently reported to have a key role in tumor progression. However, the clinical significance of NUCB2 in colorectal cancer (CRC) remains unknown. In the present study, the level of NUCB2...

journal_title：Oncology letters

authors： Xie J,Chen L,Chen W

更新日期：2018-06-01 00:00:00

abstract：:Lung cancer is a major cause of death worldwide, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The aim of this study was to investigate whether miR-96 mediated the invasion and metastasis of NSCLC by targeting glypican-3 (GPC3). Reverse transcription-quantitative PCR (RT-qPCR) was empl...

journal_title：Oncology letters

authors： Fei X,Zhang J,Zhao Y,Sun M,Zhao H,Li S

更新日期：2018-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical utility of plasma chromogranin A (CgA) in patients diagnosed with early-stage pancreatic neuroendocrine tumors (PNETs) in terms of diagnostic value and treatment response. A total of 35 patients with PNETs were prospectively enrolled from August 2010 to April 2...

journal_title：Oncology letters

authors： Tseng CM,Cheng TY,Chen TB,Tien YW,Chen CC,Lin JT,Wang HP

更新日期：2018-06-01 00:00:00